Using Cooperatively Folded Peptides To Measure Interaction Energies and Conformational Propensities
نویسندگان
چکیده
منابع مشابه
Short-range conformational energies, secondary structure propensities, and recognition of correct sequence-structure matches.
A statistical analysis of known structures is made for an assessment of the utility of short-range energy considerations. For each type of amino acid, the potentials governing (1) the torsions and bond angle changes of virtual C alpha-C alpha bonds and (2) the coupling between torsion and bond angle changes are derived. These contribute approximately -2 RT per residue to the stability of native...
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Conformational ensembles of individual amino acid residues within model GxG peptides (x representing different amino acid residues) are dominated by a mixture of polyproline II (pPII) and β-strand like conformations. We recently discovered rather substantial differences between the enthalpic and entropic contributions to this equilibrium for different amino acid residues. Isoleucine and valine ...
متن کاملDesign of folded peptides.
1. Helices 3131 2. â-Turn and Hairpin Nucleation 3132 B. Conformational Control 3133 1. Helix Nucleation 3134 2. Design of â-Turns and Hairpins 3135 3. Design of Multiple-Stranded Sheets 3137 C. Use of Templates 3137 III. Assembly of Secondary Structures 3139 A. Assembly Driven by Solvent Forces 3139 1. Helical Bundles 3139 2. â-Sheet Assembly 3141 3. R/â Mixed Assemblies 3143 B. Template-Assis...
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هدف از این مطالعه بررسی امکان استفاده از داروهای شناخته شده در درمان سایر بیماریها به عنوان داروهای ضد سرطان است. همچنین با استفاده از این داروها در ساختمان کمپلکس فلز می توان شاخص های دارویی بدست آمده را بررسی نمود. داروی ضد ویروس ایدز(hiv)به نام زیدوودین(azt)انتخاب و.کمپلکس.محلول.در.آب[pt(azt)2]cl2سنتزو به روشهای مختلف فیزیکی و شیمیایی شناسایی گردید. بر هم کنش مقایسه ای این دارو و کمپلکس پلا...
15 صفحه اولHelix capping propensities in peptides parallel those in proteins.
Helix content of peptides with various uncharged nonaromatic amino acids at either the N-terminal or C-terminal position has been determined. The choice of N-terminal amino acid has a major effect on helix stability: asparagine is the best, glycine is very good, and glutamine is the worst helix-stabilizing amino acid at this position. The rank order of helix stabilization parallels the frequenc...
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ژورنال
عنوان ژورنال: Accounts of Chemical Research
سال: 2017
ISSN: 0001-4842,1520-4898
DOI: 10.1021/acs.accounts.7b00195